Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) – Masquerade Diagnosis: A Case Report
نویسندگان
چکیده
منابع مشابه
Neuropsychiatric Systemic Lupus Erythematosus
Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been s...
متن کاملA Case of Systemic Lupus Erythematosus
SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...
متن کاملNeuroimmunological and clinical studies in Neuropsychiatric Lupus Erythematosus (NPSLE)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with many organ manifestations and characteristic immunological abnormities including a large set of autoantibodies with affinity for nuclear and membrane components. Autoantibodies form immune complexes, which cause inflammation and tissue damage in affected organs. Neuropsychiatric symptoms in SLE (NPSLE) are common, but clini...
متن کاملPTPN22 and TYK2 genes polymorphisms contribute to neuropsychiatric systemic lupus erythematosus (NPSLE) in Chinese Han
Background: Neuropsychiatric manifestations pose diagnostic and therapeutic challenges in systemic lupus erythematosus (SLE). The aim of this study was to investigate whether the PTPN22, IRF5 and TYK2 polymorphisms are involved in the development of NPSLE. Material and methods: The association was investigated between three immune-associated genes (PTPN22, IRF5 and TYK2) polymorphisms and SLE p...
متن کاملNeuropsychiatric Systemic Lupus Erythematosus: A Diagnostic Conundrum
A 70-year-old man presented with complaints of rapid cognitive decline and new onset leukopenia. The patient had a 17-year history of refractory seizures. Detailed review of symptoms and investigations revealed the patient met American College of Rheumatology (ACR) diagnostic criteria for systemic lupus erythematosus (SLE). The patient had high titer ANA with a strongly positive dsDNA. Immunosu...
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ژورنال
عنوان ژورنال: IIUM Medical Journal Malaysia
سال: 2020
ISSN: 2735-2285,1823-4631
DOI: 10.31436/imjm.v18i2.581